Evolution of Acridines and Xanthenes as a Core Structure for the Development of Antileishmanial Agents

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Silva, CFM (Autor) Outra; Pinto, DCGA (Autor) Outra; Pedro A Fernandes (Autor) FCUP; Silva, AMS (Autor) Outra

Revista

Título: Pharmaceuticals

Vol. 455

Página Final: 148

ISSN: 1424-8247

Editora: MDPI

Indexação

ISI Web of Knowledge - 10 Citações

Scopus - 11 Citações

Outras Informações

ID Authenticus: P-00W-1SG

DOI: 10.3390/ph15020148

Abstract (EN): Nowadays, leishmaniasis constitutes a public health issue in more than 88 countries, affecting mainly people from the tropics, subtropics, and the Mediterranean area. Every year, the prevalence of this infectious disease increases, with the appearance of 1.5-2 million new cases of cutaneous leishmaniasis and 500,000 cases of visceral leishmaniasis, endangering approximately 350 million people worldwide. Therefore, the absence of a vaccine or effective treatment makes the discovery and development of new antileishmanial therapies one of the focuses for the scientific community that, in association with WHO, hopes to eradicate this disease shortly. This paper is intended to highlight the relevance of nitrogen- and oxygen-containing tricyclic heterocycles, particularly acridine and xanthene derivatives, for the development of treatments against leishmaniasis. Thus, in this review, a thorough compilation of the most promising antileishmanial acridine and xanthene derivatives is performed from both natural and synthetic origins. Additionally, some structure-activity relationship studies are also depicted and discussed to provide insight into the optimal structural features responsible for these compounds' antileishmanial activity.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 22