Boosting Antimicrobial Activity of Ciprofloxacin by Functionalization of Mesoporous Silica Nanoparticles

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Mora, BD (Autor) Outra; Filipe, L (Autor) Outra; Forte, A (Autor) Outra; Santos, MM (Autor) FCUP; Alves, C (Autor) Outra; Teodoro, F (Autor) Outra; Pedrosa, R (Autor) Outra; Carrott, MR (Autor) Outra; Branco, LC (Autor) Outra; Gago, S (Autor) Outra

Revista

Título: Pharmaceutics

Vol. 13

Páginas: 1-16

ISSN: 1999-4923

Editora: MDPI

Indexação

ISI Web of Knowledge - 8 Citações

Scopus - 8 Citações

Outras Informações

ID Authenticus: P-00T-GAJ

DOI: 10.3390/pharmaceutics13020218

Abstract (EN): Mesoporous silica nanoparticles (MSNs) are very promising nanomaterials for treating bacterial infections when combined with pharmaceutical drugs. Herein, we report the preparation of two nanomaterials based on the immobilization of ciprofloxacin in mesoporous silica nanoparticles, either as the counter-ion of the choline derivative cation (MSN-[Ch][Cip]) or via anchoring on the surface of amino-group modified MSNs via an amide bond (MSN-Cip). Both nanomaterials were characterized by TEM, FTIR and solution H-1 NMR spectroscopies, elemental analysis, XRD and N-2 adsorption at 77 K in order to provide the desired structures. No cytotoxicity from the prepared mesoporous nanoparticles on 3T3 murine fibroblasts was observed. The antimicrobial activity of the nanomaterials was determined against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Klebsiella pneumoniae) bacteria and the results were promising against S. aureus. In the case of B. subtilis, both nanomaterials exhibited higher antimicrobial activity than the precursor [Ch][Cip], and in the case of K. pneumoniae they exhibited higher activity than neutral ciprofloxacin.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16