From Extrapolation to Precision Chemical Hazard Assessment: The Ecdysone Receptor Case Study

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Ruivo, R (Autor) Outra; Sousa, J (Autor) Outra; Neuparth, T (Autor) Outra; Geffard, O (Autor) Outra; Chaumot, A (Autor) Outra; Filipe F C Castro (Autor) FCUP; Degli Esposti, D (Autor) Outra; Santos, MM (Autor) FCUP

Revista

Título: Toxics

Vol. 173

Página Final: 6

Editora: MDPI

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 4 Citações

Outras Informações

ID Authenticus: P-00V-YTM

DOI: 10.3390/toxics10010006

Abstract (EN): Hazard assessment strategies are often supported by extrapolation of damage probabilities, regarding chemical action and species susceptibilities. Yet, growing evidence suggests that an adequate sampling of physiological responses across a representative taxonomic scope is of paramount importance. This is particularly relevant for Nuclear Receptors (NR), a family of transcription factors, often triggered by ligands and thus, commonly exploited by environmental chemicals. Within NRs, the ligand-induced Ecdysone Receptor (EcR) provides a remarkable example. Long regarded as arthropod specific, this receptor has been extensively targeted by pesticides, seemingly innocuous to non-target organisms. Yet, current evidence clearly suggests a wider presence of EcR orthologues across metazoan lineages, with unknown physiological consequences. Here, we address the state-of-the-art regarding the phylogenetic distribution and functional characterization of metazoan EcRs and provide a critical analysis of the potential disruption of such EcRs by environmental chemical exposure. Using EcR as a case study, hazard assessment strategies are also discussed in view of the development of a novel precision hazard assessment paradigm.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7