The Role of Nutraceutical Containing Polyphenols in Diabetes Prevention

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Iva Fernandes (Autor) FCUP; Joana Oliveira (Autor) FCUP; Pinho, A (Autor) Outra; Carvalho, E (Autor) Outra

Revista

Título: Metabolites

Vol. 22

Página Final: 184

ISSN: 2218-1989

Editora: MDPI

Indexação

ISI Web of Knowledge - 17 Citações

Scopus - 19 Citações

Outras Informações

ID Authenticus: P-00W-6S0

DOI: 10.3390/metabo12020184

Abstract (EN): Research in pharmacological therapy has led to the availability of many antidiabetic agents. New recommendations for precision medicine and particularly precision nutrition may greatly contribute to the control and especially to the prevention of diabetes. This scenario greatly encourages the search for novel non-pharmaceutical molecules. In line with this, the daily and long-term consumption of diets rich in phenolic compounds, together with a healthy lifestyle, may have a protective role against the development of type 2 diabetes. In the framework of the described studies, there is clear evidence that the bio accessibility, bioavailability, and the gut microbiota are indeed affected by: the way phenolic compounds are consumed (acutely or chronically; as pure compounds, extracts, or in-side a whole meal) and the amount and the type of phenolic compounds (ex-tractable or non-extractable/macromolecular antioxidants, including non-bioavailable polyphenols and plant matrix complexed structures). In this review, we report possible effects of important, commonly consumed, phenolic-based nutraceuticals in pre-clinical and clinical diabetes studies. We highlight their mechanisms of action and their potential effects in health promotion. Translation of this nutraceutical-based approach still requires more and larger clinical trials for better elucidation of the mechanism of action toward clinical applications.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 28