Lipid nanoparticles biocompatibility and cellular uptake in a 3D human lung model

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Magalhães, J (Autor) Outra; Pinheiro, M (Autor) Outra; Drasler, B (Autor) Outra; Septiadi, D (Autor) Outra; Petri Fink, A (Autor) Outra; Santos, SG (Autor) Outra; Rothen Rutishauser, B (Autor) Outra; Salette Reis (Autor) FFUP

Revista

Título: Nanomedicine

Vol. 15 Nº 6

Páginas: 259-271

ISSN: 1743-5889

Editora: Future Medicine Ltd.

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 3 Citações

Outras Informações

ID Authenticus: P-00R-Q0A

DOI: 10.2217/nnm-2019-0256

Abstract (EN): Aim: Design nanostructured lipid carriers (NLC) to facilitate drug delivery to tuberculosis-infected areas, exploiting macrophage mannose receptors and assess their uptake in a 3D human lung model. Materials & methods: NLCs and mannosylated-NLCs were synthetized and characterized. Their uptake and biocompatibility were tested in a 3D human lung model. Results: The formulations have appropriate size (170-202 nm) and morphology for lung deposition. Cell membrane integrity was maintained and no significant pro-inflammatory cytokine (IL-1ß, IL-8 and TNF-¿) secretion or morphological changes were observed 24 h post nanoparticles exposure. NLCs and mannosylated NLCs were distributed in the apical side of the lung tissue, both in macrophages and in epithelial cells. Conclusion: NLCs are biocompatible carriers and can be used for pulmonary drug delivery. © 2019 Salette Rice.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13