Modulation of Macrophages M1/M2 Polarization Using Carbohydrate-Functionalized Polymeric Nanoparticles

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2021

Autores

Andrade, RGD (Autor) Outra; Reis, B (Autor) Outra; Benjamin Costas (Autor) ICBAS; Lima, SAC (Autor) Outra; Salette Reis (Autor) FFUP

Revista

Título: Polymers

Vol. 13

Páginas: 1-18

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 2 Citações

Outras Informações

ID Authenticus: P-00T-82D

DOI: 10.3390/polym13010088

Abstract (EN): Exploiting surface endocytosis receptors using carbohydrate-conjugated nanocarriers brings outstanding approaches to an efficient delivery towards a specific target. Macrophages are cells of innate immunity found throughout the body. Plasticity of macrophages is evidenced by alterations in phenotypic polarization in response to stimuli, and is associated with changes in effector molecules, receptor expression, and cytokine profile. M1-polarized macrophages are involved in pro-inflammatory responses while M2 macrophages are capable of anti-inflammatory response and tissue repair. Modulation of macrophages' activation state is an effective approach for several disease therapies, mediated by carbohydrate-coated nanocarriers. In this review, polymeric nanocarriers targeting macrophages are described in terms of production methods and conjugation strategies, highlighting the role of mannose receptor in the polarization of macrophages, and targeting approaches for infectious diseases, cancer immunotherapy, and prevention. Translation of this nanomedicine approach still requires further elucidation of the interaction mechanism between nanocarriers and macrophages towards clinical applications.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 18