Rationalizing antimicrobial therapy in the ICU: a narrative review

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2019

Autores

Timsit, JF (Autor) Outra; Bassetti, M (Autor) Outra; Cremer, O (Autor) Outra; Daikos, G (Autor) Outra; de Waele, J (Autor) Outra; Kallil, A (Autor) Outra; Kipnis, E (Autor) Outra; Kollef, M (Autor) Outra; Laupland, K (Autor) Outra; Paiva, J-A (Autor) FMUP; Rodriguez Bano, J (Autor) Outra; Ruppe, E (Autor) Outra; Salluh, J (Autor) Outra; Taccone, FS (Autor) Outra; Weiss, E (Autor) Outra; Barbier, F (Autor) Outra

Revista

Título: Intensive Care Medicine

Vol. 45

Páginas: 172-189

ISSN: 0342-4642

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 83 Citações

Scopus - 88 Citações

Outras Informações

ID Authenticus: P-00Q-4Y3

DOI: 10.1007/s00134-019-05520-5

Abstract (EN): The massive consumption of antibiotics in the ICU is responsible for substantial ecological side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this environment. Strikingly, up to half of ICU patients receiving empirical antibiotic therapy have no definitively confirmed infection, while de-escalation and shortened treatment duration are insufficiently considered in those with documented sepsis, highlighting the potential benefit of implementing antibiotic stewardship programs (ASP) and other quality improvement initiatives. The objective of this narrative review is to summarize the available evidence, emerging options, and unsolved controversies for the optimization of antibiotic therapy in the ICU. Published data notably support the need for better identification of patients at risk of MDRB infection, more accurate diagnostic tools enabling a rule-in/rule-out approach for bacterial sepsis, an individualized reasoning for the selection of single-drug or combination empirical regimen, the use of adequate dosing and administration schemes to ensure the attainment of pharmacokinetics/pharmacodynamics targets, concomitant source control when appropriate, and a systematic reappraisal of initial therapy in an attempt to minimize collateral damage on commensal ecosystems through de-escalation and treatment-shortening whenever conceivable. This narrative review also aims at compiling arguments for the elaboration of actionable ASP in the ICU, including improved patient outcomes and a reduction in antibiotic-related selection pressure that may help to control the dissemination of MDRB in this healthcare setting.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 18