A Hydrophilic Sulfated Resveratrol Derivative for Topical Application: Sensitization and Anti-Allergic Potential

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Jesus, A (Autor) Outra; Sebastiao, AI (Autor) Outra; Brites, G (Autor) Outra; Marta Correia da Silva (Autor) FFUP; Honorina Cidade (Autor) FFUP; Cruz, MT (Autor) Outra; Emilia Sousa (Autor) FFUP; Almeida, IF (Autor) FFUP

Revista

Título: Molecules

Vol. 28 Nº 3

Página Final: 3158

ISSN: 1420-3049

Editora: MDPI

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 3 Citações

Outras Informações

ID Authenticus: P-00Y-5T8

DOI: 10.3390/molecules28073158

Abstract (EN): Resveratrol (RSV), a naturally occurring metabolite, is widely used in skincare products, but its hydrophobicity impairs its own incorporation into cosmetic formulations. RSV-GS is a synthetic hydrophilic sulfated glycosylated derivative inspired by marine natural products that present a lower cytotoxicity than RSV while exhibiting similar levels of bioactivity. Herein, we predict the skin sensitization potential of this new compound using an in vitro approach based on the OECD 442E guideline. Furthermore, the anti-allergic potential of RSV-GS was also disclosed. The monocyte THP-1 cell line was stimulated with RSV and RSV-GS in the presence or absence of the extreme skin allergen 1-fluoro-2,4-dinitrobenzene (DNFB). The results demonstrated that RSV-GS alone (500 mu M) evoked a relative fluorescence index (RFI) lower than the thresholds established by the OECD guideline for CD54 (200%) and CD86 (150%), indicating the absence of a skin sensitization potential. Interestingly, in the presence of the skin allergen DNFB, RSV-GS exhibited the ability to rescue the DNFB-induced maturation of THP-1 cells, with RFI values lower than those for RSV, suggesting the potential of RSV-GS to mitigate skin sensitization evoked by allergens and, consequently, allergic contact dermatitis. These results open new avenues for the use of RSV-GS as a safe and anti-allergic active cosmetic ingredient.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10