Xanthene Derivatives Targeting Bacterial Efflux Pumps, Quorum-Sensing, and Biofilm Formation

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Maia, M (Autor) Outra; Durães, F (Autor) Outra; Resende, DISP (Autor) Outra; Szemerédi, N (Autor) Outra; Gales, L (Autor) Outra; Martins da Costa, P (Autor) Outra; Pinto, M (Autor) Outra; Spengler, G (Autor) Outra; Sousa, E (Autor) FFUP

Revista

Título: Drugs and Drug Candidates

Vol. 1

Páginas: 29-42

Editora: MDPI

Indexação

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Crossref

Outras Informações

ID Authenticus: P-00Y-5FV

DOI: 10.3390/ddc1010004

Abstract (EN): <jats:p>The rise of multidrug resistance (MDR) bacteria in nosocomial and health-care institutions is widespread and is currently recognized as a major medical challenge. Mechanisms of bacterial resistance, namely, quorum sensing (QS), biofilm formation, and efflux pumps, have been identified as critical biological processes in MDR bacteria. Following previous reports on the activity of phenothiazines against mechanisms of bacterial resistance, in this work we focus on the synthesis of xanthene derivatives aiming to discover phenothiazine bioisosteres with improved activity. Four compounds were obtained from the conjugation of xanthydrol with sulfonamides and aniline and were fully characterized. Their antibacterial activity was assessed considering their minimum inhibitory concentration (MIC) against Gram-positive and Gram-negative strains, efflux pump inhibition, influence on biofilm formation and quorum-sensing (QS) inhibition. It was observed that the MIC of all the tested compounds was above 64 µg/mL The four 9-xanthenyl derivatives obtained, particularly the xanthene sulfonamide derivatives 3b and 3c, showed promising results on QS inhibition with a reduction of pigment production of 48 and 41 mm, and on biofilm formation with a reduction of 78 and 79%, respectively.</jats:p>

Idioma: Inglês

Tipo (Avaliação Docente): Científica