Interleukin-6, infection and cardiovascular outcomes in acute heart failure: Findings from the EDIFICA registry

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Vasques-Novoa, F (Autor) FMUP; Ferriera, JP (Autor) FMUP; Marques, P (Autor) Outra; Neves, JS (Autor) FMUP; Vale, C (Autor) Outra; Ribeirinho-Soares, P (Autor) Outra; Marques, J (Autor) Outra; Martins, S (Autor) Outra; guimaraes, jt (Autor) FMUP; Barros, AS (Autor) FMUP; Leite-Moreira AF (Autor) FMUP; Roncon-Albuquerque R Jr (Autor) FMUP; Almeida, J (Autor) Outra; Bettencourt P (Autor) Outra; Friões F (Autor) FMUP

Revista

Título: Cytokine

Vol. 160

ISSN: 1043-4666

Editora: Elsevier

Indexação

ISI Web of Knowledge - 10 Citações

Scopus - 11 Citações

Outras Informações

ID Authenticus: P-00X-74X

DOI: 10.1016/j.cyto.2022.156053

Abstract (EN): Aims: Interleukin-6 (IL-6) is upregulated in response to infectious and inflammatory triggers and independently predicts all-cause mortality in acute heart failure (AHF). However, the association of IL-6 with cardiovascular outcomes and its interplay with C-reactive protein and infection, a major precipitating factor in AHF, remains poorly understood.Methods and results: The association between IL-6 and clinical outcomes (180 days) in AHF was evaluated using a cohort of 164 patients from the EDIFICA registry. Median IL-6 levels at admission were 17.4 pg/mL. Patients in the higher admission IL-6 tertile presented with lower blood pressure and more congestion, were diagnosed more frequently with infection, and had a longer hospital stay. Higher IL-6 levels were associated with increased risk of HF rehospitalization (hazard ratio per log2 3.69, 95% confidence interval (CI) 1.26-10.8, p =.017) and the composite of HF rehospitalization or cardiovascular death (hazard ratio per log2 3.50; 95% CI 1.28-9.57; p =.014), independently of major AHF prognosticators, including B-type natriuretic peptide and renal function. However, no independent associations were found for all-cause rehospitalization or mortality. Despite a mod-erate correlation of IL-6 with C-reactive protein (CRP) levels (R = .51), the latter were not associated with clinical outcomes in this population.Conclusions: IL-6 levels associate with higher rate of cardiovascular events in AHF, independently of classical prognosticators and evidence of infection, outperforming CRP as an inflammatory outcome biomarker.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4