Release kinetics and cell viability of ibuprofen nanocrystals produced by melt-emulsification

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Fernandes, AR (Autor) Outra; Dias Ferreira, J (Autor) Outra; Cabral, C (Autor) Outra; Garcia, ML (Autor) Outra; Souto, EB (Autor) Outra

Revista

Título: Colloids and Surfaces B: Biointerfaces

Vol. 166

Páginas: 24-28

ISSN: 0927-7765

Editora: Elsevier

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 17 Citações

Outras Informações

ID Authenticus: P-00N-Q9F

DOI: 10.1016/j.colsurfb.2018.03.005

Abstract (EN): The clinical use of poorly water-soluble drugs has become a big challenge in pharmaceutical development due to the compromised bioavailability of the drugs in vivo. Nanocrystals have been proposed as a formulation strategy to improve the dissolution properties of these drugs. The benefits of using nanocrystals in drug delivery, when compared to other nanoparticles, are related to their production facilities, simple structure, and suitability for a variety of administration routes. High pressure homogenization (HPH) is the most promising production process, which can be employed at low or high temperatures. Ibuprofen nanocrystals with a mean size below 175 nm, and polydispersity below 0.18, have been produced by melt emulsification, followed by HPH. Two nanocrystal formulations, differing on the surfactant composition, have been produced, their in vitro ibuprofen release tested in Franz diffusion cells and adjusted to several kinetic models (zero order, first order, Higuchi, Hixson-Crowell, Korsmeyer-Peppas, Baker-Lonsdale and Weibull model). Cell viability was assessed at 3, 6 and 24h of incubation on human epithelial colorectal cells (Caco-2) by AlamarBlue colorimetric assay. For both formulations, Caco-2 cells viability was dependent on the drug concentration and time of exposure.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5