Development, Cytotoxicity and Eye Irritation Profile of a New Sunscreen Formulation Based on Benzophenone-3-poly(epsilon-caprolactone) Nanocapsules

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Barbosa, TC (Autor) Outra; Nascimento, LED (Autor) Outra; Bani, C (Autor) Outra; Almeida, T (Autor) Outra; Nery, M (Autor) Outra; Santos, RS (Autor) Outra; Menezes, LRD (Autor) Outra; Zielinska, A (Autor) Outra; Fernandes, AR (Autor) Outra; Cardoso, JC (Autor) Outra; Jaguer, A (Autor) Outra; Jaguer, E (Autor) Outra; Sanchez Lopez, E (Autor) Outra; Nalone, L (Autor) Outra; Souto, EB (Autor) Outra; Severino, P (Autor) Outra

Revista

Título: Toxics

Vol. 7

Página Final: 51

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 10 Citações

Outras Informações

ID Authenticus: P-00R-JNE

DOI: 10.3390/toxics7040051

Abstract (EN): The objective of this work was to characterize the toxicological profile of a newly developed sunscreen formulation based on polymeric nanocapsules (NCs) loading benzophenone-3 (BZP3). NCs composed of poly(epsilon-caprolactone) carrot oil and Pluronic (R) F68 were produced by emulsification-diffusion method. Their mean particle size (Z-Ave) ranged from 280 to 420 nm, polydispersity index (PDI) was below 0.37, while zeta potential (ZP) reached about |+11 mV|. No cytotoxic effects were observed in L929 fibroblast cell line for the blank (i.e., non-loaded) NCs and BZP3-loaded NCs (BZP3-NCs). The semi-solid sunscreen formulation was stable over time (centrifugation testing) and exhibited non-Newtonian pseudoplastic behavior, which is typical of products for topical application onto the skin. The sun protection factor (SPF) value reached 8.84, when incorporating BZP3-NCs (SPF of 8.64) into the semi-solid formulation. A synergistic effect was also observed when combining the formulation ingredients of nanocapsules, i.e., SPF of carrot oil was 6.82, blank NCs was 6.84, and BZP3-loaded NCs was 8.64. From the hen's egg-chorioallantoic membrane test (HET-CAM) test, the non-irritation profile of the developed formulations could also be confirmed. The obtained results show a promising use of poly(epsilon-caprolactone) nanocapsules to be loaded with lipophilic sunscreens as benzophenone-3.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12