DABCO-Customized Nanoemulsions: Characterization, Cell Viability and Genotoxicity in Retinal Pigmented Epithelium and Microglia Cells

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Fernandes, AR (Autor) Outra; dos Santos, T (Autor) Outra; Granja, PL (Autor) Outra; Sanchez Lopez, E (Autor) Outra; Santini, A (Autor) Outra; Garcia, ML (Autor) Outra; Silva, AM (Autor) Outra; Souto, EB (Autor) Outra

Revista

Título: Pharmaceutics

Vol. 13

Página Final: 1652

ISSN: 1999-4923

Editora: MDPI

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00V-JRC

DOI: 10.3390/pharmaceutics13101652

Abstract (EN): Quaternary derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO) and of quinuclidine surfactants were used to develop oil-in-water nanoemulsions with the purpose of selecting the best long-term stable nanoemulsion for the ocular administration of triamcinolone acetonide (TA). The combination of the best physicochemical properties (i.e., mean droplet size, polydispersity index, zeta potential, osmolality, viscoelastic properties, surface tension) was considered, together with the cell viability assays in ARPE-19 and HMC3 cell lines. Surfactants with cationic properties have been used to tailor the nanoemulsions' surface for site-specific delivery of drugs to the ocular structure for the delivery of TA. They are tailored for the eye because they have cationic properties that interact with the anionic surface of the eye.</p>

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 17