Preparation and ex vivo investigation of an injectable microparticulate formulation for gastrointestinal mucosa polyp resection

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Moles Aranda, C (Autor) Outra; Perez Gonzalez, N (Autor) Outra; Calpena Campmany, AC (Autor) Outra; Martin Villena, MJ (Autor) Outra; Otero Espinar, FJ (Autor) Outra; Severino, P (Autor) Outra; Souto, EB (Autor) FFUP; Morales Molina, JA (Autor) Outra; Clares Naveros, B (Autor) Outra

Revista

Título: European Journal of Pharmaceutics and Biopharmaceutics

Vol. 178

Páginas: 25-34

ISSN: 0939-6411

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00X-0YD

DOI: 10.1016/j.ejpb.2022.07.012

Abstract (EN): Endoscopic submucosal dissection (ESD) and endoscopic submucosal resection (EMR) are non-invasive endo-scopic techniques. They allow an early excised gastrointestinal (GI) mucosal precancerous lessions. For their application is necessary to use a submucosal injection that lifts the area to excise. The main objective of this study was the preparation of a microparticulate-based fluid for injection in the GI submucosa. Alginate microparticles (MPs) were developed by the solvent displacement technique and characterized by particle size, surface electrical properties, swelling, degradation, rheology, adhesion, leakage, syringeablity and stability. Furthermore, their potential to form a submucosal cushion was assayed in porcine stomach mucosa and porcine colon mucosa. Results showed MPs sizes below 160 mu m, negative surface charge around-50 mV at pH = 6, high rates of swelling and good adhesion. The microparticulate-based fluid exhibited pseudoplastic behavior following the Ostwald-de Waele rheological model. A brief force is sufficient for its injection through a syringe. Finally, for-mulations were able to provide a submucosa elevation of 1.70 cm for more than 90 min and 120 min in the porcine stomach and colon, respectively.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10