Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Pereira, D (Autor) Outra; Pinto, M (Autor) Outra; Marta Correia da Silva (Autor) FFUP; Honorina Cidade (Autor) FFUP

Revista

Título: Molecules

Nº de Série 3 Vol. 27 Nº 969

Página Final: 230

ISSN: 1420-3049

Editora: MDPI

Indexação

ISI Web of Knowledge - 35 Citações

Scopus - 34 Citações

Outras Informações

ID Authenticus: P-00V-YRC

DOI: 10.3390/molecules27010230

Abstract (EN): As a result of the biological activities of natural flavonoids, several synthetic strategies aiming to obtain analogues with improved potency and/or pharmacokinetic profile have been developed. Since the triazole ring has been associated with several biological activities and metabolic stability, hybridization with a 1,2,3-triazole ring has been increasingly reported over the last years. The feasible synthesis through copper (I) catalyzed azide-alkyne cycloaddition (CuAAC) has allowed the accomplishment of several hybrids. Since 2017, almost 700 flavonoid hybrids conjugated with 1,2,3-triazole, including chalcones, flavones, flavanones and flavonols, among others, with antitumor, antimicrobial, antidiabetic, neuroprotective, anti-inflammatory, antioxidant, and antifouling activity have been reported. This review compiles the biological activities recently described for these hybrids, highlighting the mechanism of action and structure-activity relationship (SAR) studies.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 43