Drugs of abuse and kidney toxicity

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Silva, JP (Autor) Outra; Helena Carmo (Autor) FFUP; Felix Carvalho (Autor) FFUP

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: CURRENT OPINION IN TOXICOLOGY

Vol. 32

ISSN: 2468-2020

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00W-Y61

DOI: 10.1016/j.cotox.2022.100360

Abstract (EN): The increasing consumption of drugs of abuse represents a global public health concern. Kidneys are especially vulnerable to the toxic effects of these substances, as these organs are involved in their filtration, concentration and metabolism to potentially toxic metabolites. Distinct clinical manifestations known to precede acute and chronic kidney injury (e.g., rhabdomyolysis, vasoconstriction, decreased estimated glomerular filtration rate) have been reported for different drugs of abuse (e.g., cannabinoids, cocaine, opioids, substituted phenethylamines). However, the underlying mechanisms remain poorly understood. As such, we herein review the most recent updates on the nephrotoxicity associated with drugs of abuse, as understanding their nephrotoxic profile assumes major relevance to improve risk assessment and therapeutic responses to drug-related complications.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7