Protective Role of Flavonoids against Intestinal Pro-Inflammatory Effects of Silver Nanoparticles

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Rufino, AT (Autor) Outra; Ramalho, A (Autor) Outra; Sousa, A (Autor) Outra; de Oliveira, JMPF (Autor) FFUP; Freitas, P (Autor) Outra; Gomez, MAG (Autor) Outra; Pineiro Redondo, Y (Autor) Outra; Rivas, J (Autor) Outra; Felix Carvalho (Autor) FFUP; Eduarda Fernandes (Autor) FFUP; Freitas, M (Autor) Outra

Revista

Título: Molecules

Vol. 176

Página Final: 6610

ISSN: 1420-3049

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00V-N85

DOI: 10.3390/molecules26216610

Abstract (EN): Silver nanoparticles (AgNP) have been increasingly incorporated into food-related and hygiene products for their unique antimicrobial and preservative properties. The consequent oral exposure may then result in unpredicted harmful effects in the gastrointestinal tract (GIT), which should be considered in the risk assessment and risk management of these materials. In the present study, the toxic effects of polyethyleneimine (PEI)-coated AgNP (4 and 19 nm) were evaluated in GIT-relevant cells (Caco-2 cell line as a model of human intestinal cells, and neutrophils as a model of the intestinal inflammatory response). This study also evaluated the putative protective action of dietary flavonoids against such harmful effects. The obtained results showed that AgNP of 4 and 19 nm effectively induced Caco-2 cell death by apoptosis with concomitant production of nitric oxide, irrespective of the size. It was also observed that AgNP induced human neutrophil oxidative burst. Interestingly, some flavonoids, namely quercetin and quercetagetin, prevented the deleterious effects of AgNP in both cell types. Overall, the data of the present study provide a first insight into the promising protective role of flavonoids against the potentially toxic effects of AgNP at the intestinal level.</p>

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 19