The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells

• Tipo: Artigo em Revista Científica Internacional
• Data: 2016

Autores

Chorny, A (Autor) Outra; Casas Recasens, S (Autor) Outra; Sintes, J (Autor) Outra; Shan, M (Autor) Outra; Polentarutti, N (Autor) Outra; Garcia Escudero, R (Autor) Outra; Walland, AC (Autor) Outra; Yeiser, JR (Autor) Outra; Cassis, L (Autor) Outra; Carrillo, J (Autor) Outra; Puga, I (Autor) Outra; Cunha, C (Autor) Outra; Bastos, H (Autor) Outra; Rodrigues, F (Autor) Outra; Lacerda, JF (Autor) Outra; Morais, A (Autor) Outra; Dieguez Gonzalez, R (Autor) Outra; Heeger, PS (Autor) Outra; Salvatori, G (Autor) Outra; Carvalho, A (Autor) Outra; Garcia Sastre, A (Autor) Outra; Blander, JM (Autor) Outra; Mantovani, A (Autor) Outra; Garlanda, C (Autor) Outra; Cerutti, A (Autor) Outra

Revista

Título: Journal of Experimental Medicine

Vol. 213

Páginas: 2167-2185

ISSN: 0022-1007

Editora: Rockefeller University Press

Indexação

ISI Web of Knowledge - 43 Citações

Scopus - 45 Citações

Outras Informações

ID Authenticus: P-00M-3CV

DOI: 10.1084/jem.20150282

Abstract (EN): Pentraxin 3 (PTX3) is a fluid-phase pattern recognition receptor of the humoral innate immune system with ancestral antibody-like properties but unknown antibody-inducing function. In this study, we found binding of PTX3 to splenic marginal zone (MZ) B cells, an innate-like subset of antibody-producing lymphocytes strategically positioned at the interface between the circulation and the adaptive immune system. PTX3 was released by a subset of neutrophils that surrounded the splenic MZ and expressed an immune activation-related gene signature distinct from that of circulating neutrophils. Binding of PTX3 promoted homeostatic production of IgM and class-switched IgG antibodies to microbial capsular polysaccharides, which decreased in PTX3-deficient mice and humans. In addition, PTX3 increased IgM and IgG production after infection with blood-borne encapsulated bacteria or immunization with bacterial carbohydrates. This immunogenic effect stemmed from the activation of MZ B cells through a neutrophil-regulated pathway that elicited class switching and plasmablast expansion via a combination of T cell-independent and T cell-dependent signals. Thus, PTX3 may bridge the humoral arms of the innate and adaptive immune systems by serving as an endogenous adjuvant for MZ B cells. This property could be harnessed to develop more effective vaccines against encapsulated pathogens.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 19