Long-term effects of parathyroid hormone, 1,25-dihydroxyvitamin D-3, and dexamethasone on the cell growth and functional activity of human osteogenic alveolar bone cell cultures

• Tipo: Artigo em Revista Científica Internacional
• Data: 2000

Autores

Costa, MA (Autor) ICBAS; Fernandes MH (Autor) FMDUP

Revista

Título: Pharmacological Research

Vol. 42

Páginas: 345-353

ISSN: 1043-6618

Editora: Elsevier

Indexação

ISI Web of Knowledge - 18 Citações

Scopus - 19 Citações

Outras Informações

ID Authenticus: P-000-YXH

DOI: 10.1006/phrs.2000.0697

Abstract (EN): The proliferation-differentiation behaviour of human alveolar bone cell cultures grown for 32 days in conditions that allowed the complete expression of the osteoblastic phenotype was significantly affected by the continuous presence of parathyroid hormone, 1,25-dihydroxyvitamin D-3, or dexamethasone. Parathyroid hormone and, in particular, dexamethasone significantly induced the differentiation of osteoblastic cells. Moreover, cultures exposed to these hormones presented an earlier appearance and higher levels of alkaline phosphatase, and an increased ability to form calcium phosphate deposits in the extracellular matrix. (C) 2000 Academic Press.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9