Trehalose is not a universal solution for solid lipid nanoparticles freeze-drying

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Doktorovova, S (Autor) Outra; Shegokar, R (Autor) Outra; Fernandes, L (Autor) Outra; Martins Lopes, P (Autor) Outra; Silva, AM (Autor) Outra; Mueller, RH (Autor) Outra; Souto, EB (Autor) Outra

Revista

Título: Pharmaceutical Development and Technology

Vol. 19

Páginas: 922-929

ISSN: 1083-7450

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 25 Citações

Outras Informações

ID Authenticus: P-006-HT0

DOI: 10.3109/10837450.2013.840846

Abstract (EN): Objective: To prepare stable and easy to handle formulation of solid lipid nanoparticles (SLNs) by freeze-drying with or without cryoprotectants, as appropriate. Materials and methods: SLNs were freeze-dried without cryoprotectants or with cryoprotectants in quantities selected by freeze-thaw test (sucrose, glucose) or literature search (trehalose, maltose). Appearance, re-dispersability and size distribution of re-dispersed samples were evaluated. Results: SLN could be freeze-dried using 10% sucrose, trehalose or maltose. Trehalose was effective in protecting one of presented formulations that was already very stable on its own; its efficiency in protecting other two formulations was limited. Discussion: Our results are in line with various reports of successful freeze-drying of SLN, but considering the stability of original dispersions, no improvement was achieved. Conclusion: We confirmed that trehalose is among the most suitable cryoprotectant for SLN, however it did not improve shelf-life of the most stable formulation.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8