Nanoemulsions and nanoparticles for non-melanoma skin cancer: effects of lipid materials

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Severino, P (Autor) Outra; Fangueiro, JF (Autor) Outra; Ferreira, SV (Autor) Outra; Basso, R (Autor) Outra; Chaud, MV (Autor) Outra; Santana, MHA (Autor) Outra; Rosmaninho, A (Autor) Outra; Souto, EB (Autor) Outra

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: Clinical and Translational Oncology

Vol. 15

Páginas: 417-424

ISSN: 1699-048X

Indexação

ISI Web of Knowledge - 11 Citações

Scopus - 24 Citações

Outras Informações

ID Authenticus: P-005-085

DOI: 10.1007/s12094-012-0982-0

Abstract (EN): Basal cell carcinomas and squamous cell carcinomas are non-melanoma skin cancers reported to be among the most common malignancies, being responsible for high human morbidity. Conventional chemotherapy applied to these conditions shows non-specific targeting, thus severe adverse side effects are also commonly reported. New therapeutic strategies based on nanoparticulates technology have emerged as alternatives for site specific chemotherapy. Among the different types of nanoparticulates, lipid nanoemulsions and nanoparticles have several advantages for topical delivery of poorly soluble chemotherapeutics. These particles show sustained drug release and protection of loaded drugs from chemical degradation. This technology is promising to enhance the intracellular concentration of drugs and consequently reduce the cytotoxicity of skin chemotherapy.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8