Potential use of nanostructured lipid carriers for topical delivery of flurbiprofen

• Tipo: Artigo em Revista Científica Internacional
• Data: 2010

Autores

González-Mira, E (Autor) Outra; Nikoli¿, S (Autor) Outra; García, M (Autor) Outra; Egea, M (Autor) Outra; Souto, E (Autor) Outra; Calpena, A (Autor) Outra

Revista

Título: Journal of Pharmaceutical Sciences

Vol. 100

Páginas: 242-251

ISSN: 0022-3549

Editora: Elsevier

Indexação

ISI Web of Knowledge - 43 Citações

Scopus - 60 Citações

Outras Informações

ID Authenticus: P-00G-YSY

DOI: 10.1002/jps.22271

Abstract (EN): The potential use of nanostructured lipid carriers (NLC) composed of a fatty acid [ stearic acid (SA)] or a triglyceride (glyceryl behenate) as solid lipids, and a mixture of medium chain triglycerides and castor oil as liquid lipids, for skin administration of flurbiprofen (FB), has been explored. Two different optimized NLC formulations (FB-SANLC based on SA vs. FB-C888NLC based on glyceryl behenate), with respect to the morphometrical properties (particle size and polydispersity index) and the entrapment efficiency, were used in this study. The ex vivo permeation profiles of FB-C888NLC, FB-SANLC and conventional FB solution were evaluated using human skin. An improved FB permeation was observed when the drug was delivered by skin application of FB-C888NLC, attributed to the particle size and matrix crystallinity. The differential scanning calorimetry and X-ray diffraction studies suggested major polymorphic transitions in the lipid matrix of FB-C888NLC. A good correlation between polymorphic transitions and increased drug permeation was observed. However, both NLC dispersions showed a penetration-enhancing ratio (ER) higher than conventional FB solution. The in vitro and in vivo irritancy and local tolerability were assessed by running, respectively, the SKINTEX (TM) and Draize test. Both FB-C888NLC and FB-SANLC were classified as non-irritant. (C) 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:242-251, 2011

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10