Natural Products for the Prevention and Treatment of Oral Mucositis-A Review

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2022

Autores

Ferreira, AS (Autor) Outra; Macedo, C (Autor) Outra; Silva, AM (Autor) Outra; Delerue-Matos, C (Autor) Outra; Paulo Costa (Autor) FFUP; Rodrigues, F (Autor) Outra

Revista

Título: International Journal Of Molecular Sciences

Vol. 23

Página Final: 4385

ISSN: 1661-6596

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00W-FAH

DOI: 10.3390/ijms23084385

Abstract (EN): Cancer, a major world public health problem, is associated with chemotherapy treatments whose administration leads to secondary concerns, such as oral mucositis (OM). The OM disorder is characterized by the presence of ulcers in the oral mucosa that cause pain, bleeding, and difficulty in ingesting fluids and solids, or speaking. Bioactive compounds from natural sources have arisen as an effective approach for OM. This review aims to summarize the new potential application of different natural products in the prevention and treatment of OM in comparison to conventional ones, also providing a deep insight into the most recent clinical studies. Natural products, such as Aloe vera, Glycyrrhiza glabra, Camellia sinensis, Calendula officinalis, or honeybee crops, constitute examples of sources of bioactive compounds with pharmacological interest due to their well-reported activities (e.g., antimicrobial, antiviral, anti-inflammatory, analgesic, or wound healing). These activities are associated with the bioactive compounds present in their matrix (such as flavonoids), which are associated with in vivo biological activities and minimal or absent toxicity. Finally, encapsulation has arisen as a future opportunity to preserve the chemical stability and the drug bioa vailability of bioactive compounds and, most importantly, to improve the buccal retention period and the therapeutic effects.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 31