Cutoff Values of MASK-air Patient-Reported Outcome Measures

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Sousa Pinto, B (Autor) FMUP; Sa Sousa, A (Autor) Outra; Vieira, RJ (Autor) FMUP; Amaral, R (Autor) FMUP; Pereira, AM (Autor) FMUP; Anto, JM (Autor) Outra; Klimek, L (Autor) Outra; Czarlewski, W (Autor) Outra; Mullol, J (Autor) Outra; Pfaar, O (Autor) Outra; Bedbrook, A (Autor) Outra; Brussino, L (Autor) Outra; Kvedariene, V (Autor) Outra; Larenas Linnemann, DE (Autor) Outra; Okamoto, Y (Autor) Outra; Ventura, MT (Autor) Outra; Ansotegui, IJ (Autor) Outra; Bosnic Anticevich, S (Autor) Outra; Canonica, GW (Autor) Outra; Cardona, V (Autor) Outra; Cecchi, L (Autor) Outra; Chivato, T (Autor) Outra; Cingi, C (Autor) Outra; Costa, E (Autor) FFUP; Cruz, AA (Autor) Outra; Del Giacco, S (Autor) Outra; Devillier, P (Autor) Outra; Fokkens, WJ (Autor) Outra; Gemicioglu, B (Autor) Outra; Haahtela, T (Autor) Outra; Ivancevich, JC (Autor) Outra; Kuna, P (Autor) Outra; Kaidashev, I (Autor) Outra; Kraxner, H (Autor) Outra; Laune, D (Autor) Outra; Louis, R (Autor) Outra; Makris, M (Autor) Outra; Monti, R (Autor) Outra; Morais Almeida, M (Autor) Outra; Mosges, R (Autor) Outra; Niedoszytko, M (Autor) Outra; Papadopoulos, NG (Autor) Outra; Patella, V (Autor) Outra; Pham Thi, N (Autor) Outra; Regateiro, FS (Autor) Outra; Reitsma, S (Autor) Outra; Rouadi, PW (Autor) Outra; Samolinski, B (Autor) Outra; Sheikh, A (Autor) Outra; Sova, M (Autor) Outra; Taborda Barata, L (Autor) Outra; Toppila Salmi, S (Autor) Outra; Sastre, J (Autor) Outra; Tsiligianni, I (Autor) Outra; Valiulis, A (Autor) Outra; Yorgancioglu, A (Autor) Outra; Zidarn, M (Autor) Outra; Zuberbier, T (Autor) Outra; Fonseca, J (Autor) FMUP; Bousquet, J (Autor) Outra

Revista

Título: Journal of Allergy and Clinical Immunology: In Practice

Vol. 11

Páginas: 1281-+

ISSN: 2213-2198

Editora: Elsevier

Indexação

ISI Web of Knowledge - 12 Citações

Scopus - 12 Citações

Outras Informações

ID Authenticus: P-00X-P5V

DOI: 10.1016/j.jaip.2022.12.005

Abstract (EN): BACKGROUND: In clinical and epidemiological studies, cutoffs of patient-reported outcome measures can be used to classify patients into groups of statistical and clinical relevance. However, visual analog scale (VAS) cutoffs in MASK-air have not been tested. OBJECTIVE: To calculate cutoffs for VAS global, nasal, ocular, and asthma symptoms.METHODS: In a cross-sectional study design of all MASK-air participants, we compared (1) approaches based on the percen-tiles (tertiles or quartiles) of VAS distributions and (2) data -driven approaches based on clusters of data from 2 comparators (VAS work and VAS sleep). We then performed sensitivityanalyses for individual countries and for VAS levels corre-sponding to full allergy control. Finally, we tested the different approaches using MASK-air real-world cross-sectional and lon-gitudinal data to assess the most relevant cutoffs.RESULTS: We assessed 395,223 days from 23,201 MASK-air users with self-reported allergic rhinitis. The percentile-oriented approach resulted in lower cutoff values than the data-driven approach. We obtained consistent results in the data-driven approach. Following the latter, the proposed cutoff differenti-ating controlled and partly-controlled patients was similar to the cutoff value that had been arbitrarily used (20/100). However, a lower cutoff was obtained to differentiate between partly-controlled and uncontrolled patients (35 vs the arbitrarily-used value of 50/100).CONCLUSIONS: Using a data-driven approach, we were able to define cutoff values for MASK-air VASs on allergy and asthma symptoms. This may allow for a better classification of patients with rhinitis and asthma according to different levels of control, supporting improved disease management. (c) 2022 American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2023;11:1281-9)

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14