Application of a Fiber Optic Refractometric Sensor to Measure the Concentration of Paracetamol in Crystallization Experiments

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Soares, L (Autor) Outra; Cruz, P (Autor) Outra; Novais, S (Autor) Outra; A. Ferreira (Autor) FEUP; Frazao, O (Autor) FEUP; Susana Silva (Autor) FCUP

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: IEEE Instrumentation and Measurement Magazine

Vol. 24

Páginas: 36-40

ISSN: 10946969

Editora: Institute of Electrical and Electronics Engineers (IEEE)

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00V-8AA

DOI: 10.1109/mim.2021.9491002

Abstract (EN): A refractometric sensor was applied to measure in real-time the concentration of Active Pharmaceutical Ingredients (APIs) in crystallization experiments. Paracetamol was used as a model system due to the extensive literature available for this API. The refractometric sensor was fabricated by a simple and inexpensive method that consisted in splicing a short section of a multimode fiber to a single mode fiber. The compact geometry of this sensor, with an external diameter of just $125\ \mu\mathrm{m}$, allowed it to measure the concentration of paracetamol, both in a stirred tank crystallizer operating in batch and in an oscillatory flow crystallizer operating continuously. The proposed technique shows the potential to monitor the concentration of APIs in crystallizers of different sizes and geometries as an alternative to more expensive and complex analysis equipment.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5