Decrease of E-Cadherin Expression in Canine Cutaneous Histiocytoma Appears to be Related to its Spontaneous Regression

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Pires, I (Autor) Outra; Queiroga, FL (Autor) Outra; Alves, A (Autor) Outra; Silva, F (Autor) Outra; Lopes, C (Autor) ICBAS

Revista

Título: Anticancer Research

Vol. 29

Páginas: 2713-2717

ISSN: 0250-7005

Editora: International Institute of Anticancer Research

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 18 Citações

Outras Informações

ID Authenticus: P-003-HKW

Abstract (EN): Background: Canine cutaneous histiocytoma (CCH) is an epidermotropic tumour of Langerhans cells, most frequent in young dogs, which undergoes spontaneous regression. Materials and Methods: E-cadherin immuno-expression was analysed in ninety-three CCH, categorized according to Cockerell and Slauson (1976) criteria into four histological groups, representing different stages of tumour regression. Results: All tumours expressed membranous E-cadherin both in keratinocytes, and in tumoural cells and no differences were noted among the histological groups analysed. However, the intensity of the E-cadherin immunolabeling decreased in the presence of lymphoid infiltration and varied significantly among the groups considered (p<0.0001). Conclusion: This study strongly suggests a down-regulation of E-cadherin expression in CCH pathogenesis and progression. The loss of E-cadherin expression might represent an activation/ maturation process of the tumoural cells constituting a switch for CCH regression.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5