Expression of Cox-1 and Cox-2 in canine mammary tumours

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

Queiroga, FL (Autor) Outra; Alves, A (Autor) Outra; Pires, I (Autor) Outra; Lopes, C (Autor) ICBAS

Revista

Título: Journal of Comparative Pathology

Vol. 136

Páginas: 177-185

ISSN: 0021-9975

Editora: Elsevier

Indexação

ISI Web of Knowledge - 43 Citações

Scopus - 55 Citações

Outras Informações

ID Authenticus: P-004-C1C

DOI: 10.1016/j.jcpa.2007.01.010

Abstract (EN): The aim of this study was to investigate immunohistochemically the expression of cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) in canine mammary tumours of different histological types. Cox-1 and Cox-2 enzyme expression was evaluated in 70 mammary samples (four normal, six hyperplastic, 60 neoplastic [21 benign and 39 malignant]). Cox-1 expression was identified in all the samples, and Cox-2 in all the mammary lesions except ductal hyperplasia. Two of the four normal mammary gland samples showed focal immunoreactivity for Cox-2. Cox-1 immunoexpression did not differ significantly between benign and malignant lesions (P = 0.272). Cox-2 immunoexpression was higher in malignant tumours than in benign counterparts (P < 0.001). Of the malignant tumours, carcinosarcomas and tubulopapillary and squamous cell carcinomas had the highest Cox-2 scores. The study showed that malignant tumours had the highest values of Cox-2 expression, and Cox-2 immunolabelling was particularly intense in histological types classically associated with high malignancy. This suggests that nonsteroidal anti-inflammatory drugs (NSAIDs), particularly Cox-2 inhibitors, may have a useful role to play in the treatment of canine malignant mammary tumours.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9