Cox-2 levels in canine mammary tumors, including inflammatory mammary carcinoma: Clinicopathological features and prognostic significance

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Queiroga, FL (Autor) Outra; Perez Alenza, MD (Autor) Outra; Silvan, G (Autor) Outra; Pena, L (Autor) Outra; Lopes, C (Autor) ICBAS; Illera, JC (Autor) Outra

Revista

Título: Anticancer Research

Vol. 25

Páginas: 4269-4275

ISSN: 0250-7005

Editora: International Institute of Anticancer Research

Indexação

ISI Web of Knowledge - 43 Citações

Scopus - 49 Citações

Outras Informações

ID Authenticus: P-000-0JJ

Abstract (EN): Cyclo-oxygenase (Cox-2) plays an important role in mammary carcinogenesis, nevertheless, its role in canine mammary tumors, and particularly in inflammatory mammary carcinoma (IMC), is unknown. Tumor Cox-2 levels were analyzed by enzyme immunoassay, in post-surgical tumor homogenates of 129 mammary tumors (62 dysplasias and benign tumors, 57 malignant non-IMC and 10 IMC) from 57 female dogs. The highest Cox-2 values were detected in the IMC group. In non-1MC malignant tumors, high values of Cox-2 were related to skin ulceration (p<0.001) and tumor size (p <0. 001). The follow-up study revealed that high Cox-2 levels were related with recurrence (p=0.002), metastases (p<0.001), disease-free survival (p<0.001) and overall survival (p<0.001). This study demonstrates an association between intra-tumor Cox-2 levels and poor prognosis. The high levels found in IMC cases could indicate a special role of Cox2 in the inflammatory phenotype and open the possibility of additional new therapeutic approaches in this special type of mammary cancer in humans and dogs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7