Development of a Coelenterazine Derivative with Enhanced Superoxide Anion-Triggered Chemiluminescence in Aqueous Solution

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022-05-05

Autores

Luís Pinto da Silva (Autor) FCUP; José Pedro Silva (Autor) Outra; Patricia González-Berdullas (Autor) FCUP; Joaquim C G E Esteves da Silva (Autor) FCUP

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: CHEMOSENSORS

Vol. 10

Páginas: 174-174

Indexação

ISI Web of Knowledge - 5 Citações

Scopus

Projetos Associados

ChemiTumorTher - Quimioluminescência Marinha como uma Terapia Anticancro de Amplo Espectro com uma Selectividade e Actividade Tumoral Melhorada

Outras Informações

ID Authenticus: P-00W-GYS

DOI: 10.3390/chemosensors10050174

Abstract (EN): Superoxide anion is a reactive oxygen species (ROS) of biological interest. More specifically, it plays a role in intra- and intercellular signaling, besides being associated with conditions such as inflammation and cancer. Given this, efforts have been made by the research community to devise new sensing strategies for this ROS species. Among them, the chemiluminescent reaction of marine Coelenterazine has been employed as a sensitive and dynamic probing approach. Nevertheless, chemiluminescent reactions are typically associated with lower emissions in aqueous solutions. Herein, here we report the synthesis of a new Coelenterazine derivative with the potential for superoxide anion sensing. Namely, this novel compound is capable of chemiluminescence in a dose-dependent manner when triggered by this ROS species. More importantly, the light-emission intensities provided by this derivative were relevantly enhanced (intensities 2.13 x 10(1) to 1.11 x 10(4) times higher) in aqueous solutions at different pH conditions when compared to native Coelenterazine. The half-life of the chemiluminescent signal is also greatly increased for the derivative. Thus, a new chemiluminescence molecule with significant potential for superoxide anion sensing was discovered and reported for the first time.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14