Development of a system to adsorb drugs onto calcium phosphate materials

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Queiroz, AC (Autor) Outra; Santos, JD (Autor) FEUP; Monteiro, FJ (Autor) FEUP

Revista

Título: Journal of Materials Science: Materials in Medicine

Vol. 16

Páginas: 641-646

ISSN: 0957-4530

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 14 Citações

ISI Web of Science

Scopus - 15 Citações

COMPENDEX

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Biotecnologia ambiental

CORDIS: Ciências Tecnológicas > Engenharia > Engenharia de biomateriais

Outras Informações

ID Authenticus: P-000-2MV

DOI: 10.1007/s10856-005-2535-3

Abstract (EN): Several studies were carried out in order to reduce the systemic use of antibiotics due to the high concentration required to provide the minimum inhibitory concentration (MIC) at infected sites. The aim of this study was to develop a system of drug adsorption onto commercial hydroxyapatite (HA, Ca-10(PO4)(6)(OH)(2)) and glass reinforced hydroxyapatite (GR-HA) granules. The drug will then be released for the local treatment of periodontitis. The antibiotics used in this study were metronidazole, a specific antibiotic indicated for the systemic treatment of periodontitis, and ampicillin, a wide spectrum antibiotic. UV spectroscopy was used to measure the amount of drug adsorbed onto HA and GR-HA granules. Results showed that metronidazole was unable to adsorb on the material's surface, as opposed to ampicillin which adsorbed both onto HA and GR-HA. Preliminary release kinetics studies were carried out using a flow through dissolution system. Results are discussed in terms of the influence of the different surface characteristics of the materials on the adsorption processes. (C) 2005 Springer Science + Business Media, Inc.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6