Nutritional and Lifestyle Interventions for Age-Related Macular Degeneration: A Review

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2017

Autores

Ângela Carneiro (Autor) FMUP; Andrade, JP (Autor) FMUP

Revista

Título: Oxidative Medicine and Cellular Longevity

Vol. 2017

Páginas: 1-13

ISSN: 1942-0900

Editora: Hindawi

Indexação

ISI Web of Knowledge - 50 Citações

Scopus - 58 Citações

Outras Informações

ID Authenticus: P-00M-DAS

DOI: 10.1155/2017/6469138

Abstract (EN): Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world. In this narrative review, we will summarize the nutritional interventions evaluated in numerous observational studies and a few randomized clinical trials. The AREDS and AREDS2 studies demonstrated that supplements including vitamins C and E, beta-carotene, and zinc may reduce the progression to advanced AMD, in some patients, by 25% in five years. This is one of the few nutritional supplements known to have beneficial effects in any eye disease. Lutein/zeaxanthin supplementation may have beneficial effects in some individuals whereas omega-3 fatty acids supplementation needs to be further investigated and supported by more evidence. Genetic factors may explain the different patterns of response and explain differences found among individuals. More importantly, a combination of lifestyle behaviors such as the avoidance of smoking, physical activity, and the adoption of a healthy dietary pattern like theMediterranean diet was associated with a lower prevalence of AMD. The adoption of these lifestyles may reduce the prevalence of the early stages of AMD and decrease the number of individuals who develop advanced AMD and consequently the onerous and climbing costs associated with the treatment of this disease.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13