Neuroendocrine (Merkel-cell) carcinoma of the skin: immunocytochemical and cytomorphologic analysis on fine-needle aspirates.

• Tipo: Artigo em Revista Científica Internacional
• Data: 1990

Autores

Skoog, L (Autor) Outra; Fernando Schmitt (Autor) Outra; Tani, E (Autor) Outra

Revista

Título: Diagnostic Cytopathology

Vol. 6

Páginas: 53-57

ISSN: 8755-1039

Editora: Wiley-Blackwell

Indexação

Scopus - 30 Citações

Outras Informações

ID Authenticus: P-008-PRN

Abstract (EN): Cytomorphologic and immunocytochemical characteristics of tumor cells from fine-needle aspirates of four neuroendocrine (Merkel-cell) carcinomas of the skin are described. All aspirates were cellular with dispersed small to medium sized tumor cells with scanty cytoplasm. Many mitoses were observed. Careful scrutiny revealed a tendency of the tumor cells to form microacinar and pseudorosette formations as well as small clusters of molding cells. Immunocytochemical analysis of cytospin preparations showed a peculiar dot-like cytokeratin positivity, while neuron-specific enolase staining was more diffuse. A weak S-100 positivity was observed. This staining pattern is highly suggestive of Merkel-cell tumor. It can thus be concluded that immunocytochemical analysis in conjunction with cytomorphology on fine-needle aspirates will allow the identification of neuroendocrine carcinoma of the skin and its differentiation from other small-cell neoplasias of the skin.

Idioma: Inglês

Tipo (Avaliação Docente): Científica