The role of the glutamine transporter ASCT2 in antineoplastic therapy

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Teixeira, E (Autor) Outra; Silva, C (Autor) Outra; Martel, F (Autor) FMUP

Revista

Título: Cancer Chemotherapy and Pharmacology

ISSN: 0344-5704

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 20 Citações

Scopus - 20 Citações

Outras Informações

ID Authenticus: P-00T-BY9

DOI: 10.1007/s00280-020-04218-6

Abstract (EN): Cancer cells are metabolically reprogrammed to support their high rates of proliferation, continuous growth, survival, invasion, metastasis, and resistance to cancer treatments. Among changes in cancer cell bioenergetics, the role of glutamine metabolism has been receiving increasing attention. Increased glutaminolysis in cancer cells is associated with increased expression of membrane transporters that mediate the cellular uptake of glutamine. ASCT2 (Alanine, Serine, Cysteine Transporter 2) is a Na+-dependent transmembrane transporter overexpressed in cancer cells and considered to be the primary transporter for glutamine in these cells. The possibility of inhibiting ASCT2 for antineoplastic therapy is currently under investigation. In this article, we will present the pharmacological agents currently known to act on ASCT2, which have been attracting attention in antineoplastic therapy research. We will also address the impact of ASCT2 inhibition on the prognosis of some cancers. We conclude that ASCT2 inhibition and combination of ASCT2 inhibitors with other anti-tumor therapies may be a promising antineoplastic strategy. However, more research is needed in this area.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 18