T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments

• Tipo: Artigo em Revista Científica Internacional
• Data: 2016

Autores

Hawkins, ED (Autor) Outra; Duarte, D (Autor) FMUP; Akinduro, O (Autor) Outra; Khorshed, RA (Autor) Outra; Passaro, D (Autor) Outra; Nowicka, M (Autor) Outra; Straszkowski, L (Autor) Outra; Scott, MK (Autor) Outra; Rothery, S (Autor) Outra; Ruivo, N (Autor) Outra; Foster, K (Autor) Outra; Waibel, M (Autor) Outra; Johnstone, RW (Autor) Outra; Harrison, SJ (Autor) Outra; Westerman, DA (Autor) Outra; Quach, H (Autor) Outra; Gribben, J (Autor) Outra; Robinson, MD (Autor) Outra; Purton, LE (Autor) Outra; Bonnet, D (Autor) Outra; Lo Celso, C (Autor) Outra

Revista

Título: Nature

Vol. 538

Páginas: 518-+

ISSN: 0028-0836

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 118 Citações

Scopus - 120 Citações

Outras Informações

ID Authenticus: P-00T-90R

DOI: 10.1038/nature19801

Abstract (EN): It is widely accepted that complex interactions between cancer cells and their surrounding microenvironment contribute to disease development, chemo-resistance and disease relapse. In light of this observed interdependency, novel therapeutic interventions that target specific cancer stroma cell lineages and their interactions are being sought. Here we studied a mouse model of human T-cell acute lymphoblastic leukaemia (T-ALL) and used intravital microscopy to monitor the progression of disease within the bone marrow at both the tissue-wide and single-cell level over time, from bone marrow seeding to development/ selection of chemo-resistance. We observed highly dynamic cellular interactions and promiscuous distribution of leukaemia cells that migrated across the bone marrow, without showing any preferential association with bone marrow sub-compartments. Unexpectedly, this behaviour was maintained throughout disease development, from the earliest bone marrow seeding to response and resistance to chemotherapy. Our results reveal that T-ALL cells do not depend on specific bone marrow microenvironments for propagation of disease, nor for the selection of chemo-resistant clones, suggesting that a stochastic mechanism underlies these processes. Yet, although T-ALL infiltration and progression are independent of the stroma, accumulated disease burden leads to rapid, selective remodelling of the endosteal space, resulting in a complete loss of mature osteoblastic cells while perivascular cells are maintained. This outcome leads to a shift in the balance of endogenous bone marrow stroma, towards a composition associated with less efficient haematopoietic stem cell function1. This novel, dynamic analysis of T-ALL interactions with the bone marrow microenvironment in vivo, supported by evidence from human T-ALL samples, highlights that future therapeutic interventions should target the migration and promiscuous interactions of cancer cells with the surrounding microenvironment, rather than specific bone marrow stroma, to combat the invasion by and survival of chemo-resistant T-ALL cells.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 18