Proliferation dynamics of acute myeloid leukaemia and haematopoietic progenitors competing for bone marrow space

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Akinduro, O (Autor) Outra; Weber, TS (Autor) Outra; Ang, H (Autor) Outra; Haltalli, MLR (Autor) Outra; Ruivo, N (Autor) Outra; Duarte, D (Autor) FMUP; Rashidi, NM (Autor) Outra; Hawkins, ED (Autor) Outra; Duffy, KR (Autor) Outra; Lo Celso, C (Autor) Outra

Revista

Título: Nature Communications

Vol. 9 Nº 1

ISSN: 2041-1723

Editora: Springer Nature

Indexação

Scopus - 38 Citações

Outras Informações

ID Authenticus: P-00T-90V

DOI: 10.1038/s41467-017-02376-5

Abstract (EN): Leukaemia progressively invades bone marrow (BM), outcompeting healthy haematopoiesis by mechanisms that are not fully understood. Combining cell number measurements with a short-timescale dual pulse labelling method, we simultaneously determine the proliferation dynamics of primitive haematopoietic compartments and acute myeloid leukaemia (AML). We observe an unchanging proportion of AML cells entering S phase per hour throughout disease progression, with substantial BM egress at high levels of infiltration. For healthy haematopoiesis, we find haematopoietic stem cells (HSCs) make a significant contribution to cell production, but we phenotypically identify a quiescent subpopulation with enhanced engraftment ability. During AML progression, we observe that multipotent progenitors maintain a constant proportion entering S phase per hour, despite a dramatic decrease in the overall population size. Primitive populations are lost from BM with kinetics that are consistent with ousting irrespective of cell cycle state, with the exception of the quiescent HSC subpopulation, which is more resistant to elimination. © 2018 The Author(s).

Idioma: Inglês

Tipo (Avaliação Docente): Científica