1-Integrin Signaling Mediates Premyelinating Oligodendrocyte Survival But Is Not Required for CNS Myelination and Remyelination

• Tipo: Artigo em Revista Científica Internacional
• Data: 2006

Autores

Benninger, Y (Autor) Outra; Colognato, H (Autor) Outra; Thurnherr, T (Autor) Outra; Franklin, RJM (Autor) Outra; Leone, DP (Autor) Outra; Atanasoski, S (Autor) Outra; Nave, K (Autor) Outra; ffrench-Constant, C (Autor) Outra; Suter, U (Autor) Outra; Relvas, JB (Autor) Outra

Revista

Título: Journal of Neuroscience

Vol. 26

Páginas: 7665-7673

ISSN: 0270-6474

Editora: Society for Neuroscience

Indexação

Scopus - 82 Citações

Outras Informações

ID Authenticus: P-00J-25K

DOI: 10.1523/jneurosci.0444-06.2006

Abstract (EN): Previous reports, including transplantation experiments using dominant-negative inhibition of ß1-integrin signaling in oligodendrocyte progenitor cells, suggested that ß1-integrin signaling is required for myelination. Here, we test this hypothesis using conditional ablation of the ß1-integrin gene in oligodendroglial cells during the development of the CNS. This approach allowed us to study oligodendroglial ß1-integrin signaling in the physiological environment of the CNS, circumventing the potential drawbacks of a dominant-negative approach. We found that ß1-integrin signaling has a much more limited role than previously expected. Although it was involved in stage-specific oligodendrocyte cell survival, ß1-integrin signaling was not required for axon ensheathment and myelination per se. We also found that, in the spinal cord, remyelination occurred normally in the absence of ß1-integrin. We conclude that, although ß1-integrin may still contribute to other aspects of oligodendrocyte biology, it is not essential for myelination and remyelination in the CNS. Copyright © 2006 Society for Neuroscience.

Idioma: Inglês

Tipo (Avaliação Docente): Científica