Mechanical plasticity during oligodendrocyte differentiation and myelination

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2018

Autores

Domingues, HS (Autor) Outra; Cruz, A (Autor) Outra; Chan, JR (Autor) Outra; Relvas, JB (Autor) ICBAS; Rubinstein, B (Autor) Outra; Pinto, IM (Autor) Outra

Revista

Título: GLIA

Vol. 66

Páginas: 5-14

ISSN: 0894-1491

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 7 Citações

Scopus - 24 Citações

Outras Informações

ID Authenticus: P-00N-8BH

DOI: 10.1002/glia.23206

Abstract (EN): In the central nervous system, oligodendrocyte precursor cells are exclusive in their potential to differentiate into myelinating oligodendrocytes. Oligodendrocyte precursor cells migrate within the parenchyma and extend cell membrane protrusions that ultimately evolve into myelinating sheaths able to wrap neuronal axons and significantly increase their electrical conductivity. The subcellular force generating mechanisms driving morphological and functional transformations during oligodendrocyte differentiation and myelination remain elusive. In this review, we highlight the mechanical processes governing oligodendrocyte plasticity in a dynamic interaction with the extracellular matrix.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10