Expression of LncRNAs in HPV-induced Carcinogenesis and Cancer Cachexia: A Study in K14-HPV16 Mice

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Tânia R. Dias (Autor) Outra; Joana M. O. Santos (Autor) Outra; Diogo Estevão (Autor) Outra; Natália R. Costa (Autor) Outra; Verónica F. Mestre (Autor) Outra; Beatriz Medeiros Fonseca (Autor) Outra; Margarida M. S. M. Bastos (Autor) FEUP; Paula A. Oliveira (Autor) Outra; Rui M. Gil da Costa da Costa (Autor) Outra; Rui Medeiros (Autor) ICBAS

Revista

Título: Anticancer Research

Vol. 42

Páginas: 2443-2460

ISSN: 0250-7005

Editora: International Institute of Anticancer Research

Indexação

ISI Web of Knowledge - 3 Citações

Scopus - 3 Citações

Outras Informações

ID Authenticus: P-00W-H3W

DOI: 10.21873/anticanres.15723

Abstract (EN): Aim: To evaluate the expression of lincRNA-p21, H19, EMX2OS, SNHG12 and MALAT1 in a mouse model of human papillomavirus 16 (HPV16)-induced carcinogenesis and cachexia. Materials and Methods: Chest skin, ear, tongue, penis and gastrocnemius muscle samples from wild-type mice (HPV-) and K14-HPV16 male mice (HPV+) were collected to evaluate the expression of the selected lncRNAs using real-time PCR (qPCR). Results: In chest skin and ear, H19, SNHG12, EMX2OS and lincRNA-p21 were down-regulated in HPV+ versus HPV- mice. In tongue and penile tissues, there was only down-regulation of lincRNA-p21 in HPV+ mice. Additionally, in penile tissue, lincRNA-p21 expression decreased in HPV-induced lesions comparing with normal tissues. In gastrocnemius muscle, MALAT1 was up-regulated and lincRNA-p21 was down-regulated in HPV+ versus HPV-mice. Conclusion: H19, SNHG12, EMX2OS and lincRNA-p21 may be involved in HPV-induced carcinogenesis. In addition, MALAT1 and lincRNA-p21 may play a role in muscle wasting and contribute to cancer cachexia.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 18