Increased expression of alpha 7nAChR in chronic rhinosinusitis: The intranasal cholinergic anti-inflammatory hypothesis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2016

Autores

Cerejeira, R (Autor) Outra; Fernandes, S (Autor) Outra; Carla Pinto Moura (Autor) FMUP

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: AURIS NASUS LARYNX

Vol. 43

Páginas: 176-181

ISSN: 0385-8146

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 6 Citações

Outras Informações

ID Authenticus: P-00K-7A3

DOI: 10.1016/j.anl.2015.08.011

Abstract (EN): Objective: Chronic rhinosinusitis results from a dysfunctional host-environment interaction at the site of interface, in the nose and paranasal sinuses. A parasympathetic-mediated anti-inflammatory reflex is known to have a pivotal role in the control of damage induced by immune response to injury and infection; acetylcholine released by peripheral nerves interacts with nicotinic acetylcholine receptor subunit alpha 7 - alpha 7nAChR - of innate immune cells, inhibiting pro-inflammatory signalling. This work aims to investigate whether cholinergic function is implicated in chronic rhinosinusitis. Methods: a7nAChR mRNA and protein levels were measured in nasal biopsy specimens of 14 patients with CRSwNP, 8 with CRSsNP and 10 control subjects, undergoing surgery. Results: Gene expression levels of a7nAChR did not differ between groups; protein expression was significantly higher in CRSwNP than in CRSsNP (p = 0.041), and both of these patient groups showed significant higher levels than controls (CRSwNP vs Controls - p = 0.001; CRSsNP vs Controls - p = 0.041). Conclusion: Elevated a7nAChR protein levels suggest that the cholinergic system is involved in the inflammatory response of chronic rhinosinusitis. This can shed light on both, the disease pathophysiology and the development of future treatment options.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6