Computational resources and strategies to assess single-molecule dynamics of the translation process in S. cerevisiae

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2021

Autores

Magalhaes, BT (Autor) Outra; Lourenco, A (Autor) Outra; Azevedo, NF (Autor) FEUP

Revista

Título: Briefings in Bioinformatics

Vol. 22

Páginas: 219-231

ISSN: 1467-5463

Editora: Oxford University Press

Indexação

ISI Web of Knowledge - 0 Citações

Outras Informações

ID Authenticus: P-00T-W93

DOI: 10.1093/bib/bbz149

Abstract (EN): This work provides a systematic and comprehensive overview of available resources for the molecular-scale modelling of the translation process through agent-based modelling. The case study is the translation in Saccharomyces cerevisiae, one of the most studied yeasts. The data curation workflow encompassed structural information about the yeast (i.e. the simulation environment), and the proteins, ribonucleic acids and other types of molecules involved in the process (i.e. the agents). Moreover, it covers the main process events, such as diffusion (i.e. motion of molecules in the environment) and collision efficiency (i.e. interaction between molecules). Data previously determined by wet-lab techniques were preferred, resorting to computational predictions/extrapolations only when strictly necessary. The computational modelling of the translation processes is of added industrial interest, since it may bring forward knowledge on how to control such phenomena and enhance the production of proteins of interest in a faster and more efficient manner.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13