Digital ulcers in systemic sclerosis: role of flow-mediated dilatation and capillaroscopy as risk assessment tools

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Silva, I (Autor) Outra; Loureiro, T (Autor) Outra; teixeira, a (Autor) FCUP; Almeida, I (Autor) Outra; Mansilha A. (Autor) FMUP; Vasconcelos, C (Autor) Outra; Almeida, R (Autor) Outra

Revista

Título: European Journal of Dermatology

Vol. 25

Páginas: 444-451

ISSN: 1167-1122

Editora: Libbey

Indexação

ISI Web of Knowledge - 7 Citações

Scopus - 8 Citações

Outras Informações

ID Authenticus: P-00K-0EY

DOI: 10.1684/ejd.2015.2605

Abstract (EN): Aim: The aim of this study was to evaluate macrovascular endothelial dysfunction and microvascular damage as clinical markers of peripheral microangiopathy in patients with Raynaud's phenomenon (RP). Patients and methods: Seventy-seven secondary RP with systemic sclerosis, 32 primary RP and 34 healthy controls were included in our study. Secondary RP patients were divided into two subgroups: 39 with digital ulcers (DU) and 38 without digital ulcers (non-DU). Results: Patients with DU had significantly lower flow-mediated dilatation values (5.34 +/- 7.49%) compared to non-DU patients (16.21 +/- 11.31%), primary RP (17.96 +/- 12.78%) and controls (20.17 +/- 8.86%), p<0.001, favouring macrovascular endothelium dysfunction. Regarding microvascular damage, the DU group had a predominately capillaroscopic late pattern (71.1%) whereas non-DU patients had an active pattern (56.4%). The microangiopathy evolution score was significantly higher in the DU group compared to the non-DU group (4.79 +/- 1.82 vs. 1.79 +/- 1.56, p<0.001). Flow-mediated dilation was significantly lower in late pattern (6.13 +/- 7.09%) compared to active (12.58 +/- 10.66%) and early patterns (17.72 +/- 14.90%), p = 0.016 and p = 0.044 respectively. Conclusions: Low flow-mediated dilatation and microvascular damage in capillaroscopy are early clinical markers of DU risk in RP patients.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8