Chromokinesins

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2018

Autores

Almeida, AC (Autor) Outra; Helder Maiato (Autor) FMUP

Revista

Título: Current Biology

Vol. 28

ISSN: 0960-9822

Editora: Elsevier

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 8 Citações

Outras Informações

ID Authenticus: P-00P-PT4

DOI: 10.1016/j.cub.2018.07.017

Abstract (EN): During the cell cycle it is critical that the duplicated DNA faithfully segregates to give rise to two genetically identical daughter cells. An even distribution of the genome during mitosis is mediated by mitotic spindle microtubules, assisted by, among others, motor proteins of the kinesin superfamily. Chromokinesins are members of the kinesin superfamily that harbour a specific DNA-binding domain. The best characterized chromokinesins belong to the kinesin-4/Kif4 and kinesin-10/Kif22 families, respectively. Functional analysis of chromokinesins in several model systems revealed their involvement in chromosome arm orientation and oscillations. This is consistent with their originally proposed role in the generation of polar ejection forces that assist chromosome congression to the spindle equator. Kinesin-12/Kif15 members comprise a third family of chromokinesins, but their role remains less understood. Noteworthy, all chromokinesins exhibit chromosome-independent localization on spindle microtubules, and recent works have significantly extended the portfolio of mitotic processes in which chromokinesins play a role, from error correction and DNA compaction, to the regulation of spindle microtubule dynamics. Chromokinesins are kinesin superfamily members that play an essential role in chromosome segregation. Here, Almeida and Maiato describe this critical function, and further highlight additional roles played by these proteins. © 2018 Elsevier Ltd

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5