From the cytoskeleton to the nucleus: An integrated view on early spindle assembly

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Luisa, TF (Autor) Outra; Helder Maiato (Autor) FMUP

Revista

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Título: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Vol. 117

Páginas: 52-61

ISSN: 1084-9521

Editora: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD

Indexação

ISI Web of Knowledge - 0 Citações

Outras Informações

ID Authenticus: P-00V-A7E

DOI: 10.1016/j.semcdb.2021.06.004

Abstract (EN): Accurate chromosome segregation requires a complete restructuring of cellular organization. Microtubules remodel to assemble a mitotic spindle and the actin cytoskeleton rearranges to form a stiff actomyosin cortex. These cytoplasmic events must be spatially and temporally coordinated with mitotic chromosome condensation and nuclear envelope permeabilization, in order to ensure mitotic timing and fidelity. Here, we discuss the main cytoskeletal and nuclear events that occur during mitotic entry in proliferating animal cells, focusing on their coordinated contribution for early mitotic spindle assembly. We will also explore recent progress in under-standing their regulatory biochemical and mechanical pathways.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10