Excess of Rare Missense Variants in Hearing Loss Genes in Sporadic Meniere Disease

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Gallego Martinez, A (Autor) Outra; Requena, T (Autor) Outra; Roman Naranjo, P (Autor) Outra; Lopez Escamez, JA (Autor) Outra; Amor Dorado, JC (Autor) Outra; Aran, I (Autor) Outra; Batuecas Caletrio, A (Autor) Outra; Benitez, J (Autor) Outra; Fraile, J (Autor) Outra; Garcia Arumi, A (Autor) Outra; Gonzalez A, R (Autor) Outra; Espinosa Sanchez, JM (Autor) Outra; Huarte, RM (Autor) Outra; Perez Fernandez, N (Autor) Outra; Marques, P (Autor) FMUP; Sanz, R (Autor) Outra; Dominguez, MO (Autor) Outra; Teggi, R (Autor) Outra

Revista

Título: Frontiers in Genetics

Vol. 10

ISSN: 1664-8021

Editora: Frontiers Media

Indexação

ISI Web of Knowledge - 30 Citações

Scopus - 30 Citações

Outras Informações

ID Authenticus: P-00Q-81K

DOI: 10.3389/fgene.2019.00076

Abstract (EN): Meniere's disease (MD) is a clinical spectrum of rare disorders characterized by vertigo attacks, associated with sensorineural hearing loss (SNHL) and tinnitus involving low to medium frequencies. Although it shows familial aggregation with incomplete phenotypic forms and variable expressivity, most cases are considered sporadic. The aim of this study was to investigate the burden for rare variation in SNHL genes in patients with sporadic MD. We conducted a targeted-sequencing study including SNHL and familial MD genes in 890 MD patients to compare the frequency of rare variants in cases using three independent public datasets as controls. Patients with sporadic MD showed a significant enrichment of missense variants in SNHL genes that was not found in the controls. The list of genes includes GJB2, USH1G, SLC26A4, ESRRB, and CLDN14. A rare synonymous variant with unknown significance was found in the MARVELD2 gene in several unrelated patients with MD. There is a burden of rare variation in certain SNHL genes in sporadic MD. Furthermore, the interaction of common and rare variants in SNHL genes may have an additive effect on MD phenotype. This study will contribute to design a gene panel for the genetic diagnosis of MD.

Idioma: Inglês

Tipo (Avaliação Docente): Divulgação

Nº de páginas: 12