Health-related Quality of Life and Utilities in Gastric Premalignant Conditions and Malignant Lesions: a Multicentre Study in a High Prevalence Country

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Areia, M (Autor) Outra; Alves, S (Autor) Outra; Brito, D (Autor) Outra; Cadime, AT (Autor) Outra; Carvalho, R (Autor) Outra; Saraiva, S (Autor) Outra; Ferreira, S (Autor) Outra; Moleiro, J (Autor) Outra; Pereira, AD (Autor) Outra; Carrasquinho, J (Autor) Outra; Lopes, L (Autor) Outra; Ramada, J (Autor) Outra; Marcos Pinto, R (Autor) Outra; Pedroto, I (Autor) ICBAS; Contente, L (Autor) Outra; Eliseu, L (Autor) Outra; Vieira, AM (Autor) Outra; Sampaio, M (Autor) Outra; Sousa, HT (Autor) Outra; Almeida, N (Autor) Outra; Gregorio, C (Autor) Outra; Portela, F (Autor) Outra; Sofia, C (Autor) Outra; Braga, V (Autor) Outra; Baginha, E (Autor) Outra; Costa, TBE (Autor) Outra; Chagas, C (Autor) Outra; Mendes, LL (Autor) Outra; Magalhaes Costa, P (Autor) Outra; Matos, L (Autor) Outra; Gonçalves F (Autor) FMUP; Mario Dinis Ribeiro (Autor) FMUP

Revista

Título: Journal of Gastrointestinal and Liver Diseases

Vol. 23

Páginas: 371-378

ISSN: 1841-8724

Editora: Editura Medicala

Indexação

ISI Web of Knowledge - 15 Citações

Scopus - 16 Citações

Outras Informações

ID Authenticus: P-00A-3BG

DOI: 10.15403/jgld.2014.1121.234.hrq

Abstract (EN): Background & Aims: A recent review of economic studies relating to gastric cancer revealed that authors use different tests to estimate utilities in patients with and without gastric cancer. Our aim was to determine the utilities of gastric premalignant conditions and adenocarcinoma with a single standardized health measure instrument. Methods: Cross-sectional nationwide study of patients undergoing upper endoscopy (n=1,434) using the EQ-5D-5L quality of life (QoL) questionnaire. Results: According to EQ-5D-5L, utilities in individuals without gastric lesions were 0.78 (95% confidence interval: 0.76-0.80), with gastric premalignant conditions 0.79 (0.77-0.81), previously treated for gastric cancer 0.77 (0.73-0.81) and with present cancer 0.68 (0.55-0.81). Self-reported QoL according to the visual analogue scale (VAS) for the same groups were 0.67 (0.66-0.69), 0.67 (0.66-0.69), 0.62 (0.59-0.65) and 0.62 (0.54-0.70) respectively. Utilities were consistently lower in women versus men (no lesions 0.71 vs. 0.78; premalignant conditions 0.70 vs.. 0.82; treated for cancer 0.72 vs. 0.78 and present cancer 0.66 vs. 0.70). Conclusion: The health-related QoL utilities of patients with premalignant conditions are similar to those without gastric diseases whereas patients with present cancer show decreased utilities. Moreover, women had consistently lower utilities than men. These results confirm that the use of a single standardized instrument such as the EQ-5D-5L for all stages of the gastric carcinogenesis cascade is feasible and that it captures differences between conditions and gender dissimilarities, being relevant information for authors pretending to conduct further cost-utility analysis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8