Age affects the prognostic impact of diabetes in chronic heart failure

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Cunha, FM (Autor) Outra; Pereira, J (Autor) Outra; Ribeiro, A (Autor) Outra; Amorim, M (Autor) Outra; Silva, S (Autor) Outra; Araújo JP (Autor) FMUP; Leite-Moreira AF (Autor) FMUP; Bettencourt P (Autor) FMUP; Lourenco, P (Autor) Outra

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: ACTA DIABETOLOGICA

Vol. 55

Páginas: 271-278

ISSN: 0940-5429

Indexação

ISI Web of Knowledge - 10 Citações

Scopus - 11 Citações

Outras Informações

ID Authenticus: P-00N-P44

DOI: 10.1007/s00592-017-1092-9

Abstract (EN): Increasing age is an established prognostic determinant in chronic heart failure (HF). Diabetes often complicates HF in its course and appears to worsen HF prognosis. A differential impact of diabetes depending on patients' age was not yet studied. We evaluated the impact of diabetes in the mortality of HF patients according to their age. We studied a cohort of chronic ambulatory HF patients prospectively recruited. Patients were on optimized evidence-based therapy, and they were excluded if on renal replacement therapy or if they had any therapy modification or hospitalizations in the previous 2 months. Patients were followed for up to 5 years; all-cause mortality was analyzed. Mortality predictors were assessed using a Cox regression. Analysis was stratified according to patient's age: cutoff 75 years. Multivariate models were built. Interaction between diabetes and age was formally tested. We studied 283 chronic HF patients; mean age was 69 years and 70.3% were male; 58.0% had severe systolic dysfunction; 105 (37.1%) were diabetic. In patients with less than 75 years, the coexistence of diabetes predicted a multivariate adjusted 1.98 (95% CI 1.13-3.46) 5-year death risk while in older patients (ae<yen> 75 years) no significant association was reported. Age interacted with the prognostic impact of diabetes, p for interaction = 0.04. The prognostic impact of diabetes in chronic HF depends on patient's age. In patients < 75 years, the coexistence of diabetes predicts an almost double risk of 5-year mortality; no such association exists in patients with 75 years or above. Diabetes predicts mortality only in younger HF patients.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8