Post-COVID-19 Condition: Where Are We Now?

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Boaventura, P (Autor) Outra; Macedo, S (Autor) Outra; Ribeiro, F (Autor) Outra; Jaconiano, S (Autor) Outra; Soares, P (Autor) FMUP

Revista

Título: LIFE-BASEL

Vol. 12

Página Final: 517

ISSN: 2075-1729

Editora: MDPI

Indexação

ISI Web of Knowledge - 20 Citações

Scopus - 21 Citações

Outras Informações

ID Authenticus: P-00W-BTD

DOI: 10.3390/life12040517

Abstract (EN): COVID-19 is currently considered a systemic infection involving multiple systems and causing chronic complications. Compared to other post-viral fatigue syndromes, these complications are wider and more intense. The most frequent symptoms are profound fatigue, dyspnea, sleep difficulties, anxiety or depression, reduced lung capacity, memory/cognitive impairment, and hyposmia/anosmia. Risk factors for this condition are severity of illness, more than five symptoms in the first week of the disease, female sex, older age, the presence of comorbidities, and a weak anti-SARS-CoV-2 antibody response. Different lines of research have attempted to explain these protracted symptoms; chronic persistent inflammation, autonomic nervous system disruption, hypometabolism, and autoimmunity may play a role. Due to thyroid high ACE expression, the key molecular complex SARS-CoV-2 uses to infect the host cells, thyroid may be a target for the coronavirus infection. Thyroid dysfunction after SARS-CoV-2 infection may be a combination of numerous mechanisms, and its role in long-COVID manifestations is not yet established. The proposed mechanisms are a direct effect of SARS-CoV-2 on target cells, an indirect effect of systemic inflammatory immune response, and a dysfunction of the hypothalamic-pituitary-thyroid (HPT) axis leading to decreased serum TSH. Only a few studies have reported the thyroid gland status in the post-COVID-19 condition. The presence of post-COVID symptoms deserves recognition of COVID-19 as a cause of post-viral fatigue syndrome. It is important to recognize the affected individuals at an early stage so we can offer them the most adequate treatments, helping them thrive through the uncertainty of their condition.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14