Metabolic syndrome and risk of cancer: Which link?

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2015

Autores

Mendonca, FM (Autor) Outra; de Sousa, FR (Autor) Outra; Barbosa, AL (Autor) Outra; Martins, SC (Autor) Outra; Araujo, RL (Autor) Outra; soares, r (Autor) FMUP; Abreu, C (Autor) FMUP

Revista

Título: Metabolism: Clinical and Experimental

Vol. 64

Páginas: 182-189

ISSN: 0026-0495

Editora: Elsevier

Indexação

ISI Web of Knowledge - 112 Citações

Scopus - 116 Citações

Outras Informações

ID Authenticus: P-00A-2ZX

DOI: 10.1016/j.metabol.2014.10.008

Abstract (EN): Metabolic syndrome (MS) is characterized by a group of metabolic-disturbances which lead to an enhanced risk of cardiovascular diseases and type 2 diabetes mellitus. MS constitutes a preoccupant issue with elevated prevalence in the western countries and is often related with cancer development. Elucidating the mechanisms linking these two pathologies is, therefore, essential to identify potential therapeutic molecular targets for cancer treatment in MS patients. The main goals of this review are, to identify the relation between MS and cancer development, handling specifically each one of the main players on this process: insulin and IGF system, estrogen, pro-inflammatory cytokines and others; and,, given that colorectal cancer is one of the most prevalent types of cancer in MS patients, we intend to particularly highlight the mechanisms that promote colorectal cancer development in MS individuals. Finally, we will also focus on the clinical implications of the presented mechanisms on cancer therapy and care.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8