Quinoxaline-1,4-dioxide derivatives inhibitory action in melanoma and brain tumor cells

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Silva, L (Autor) Outra; Coelho, P (Autor) Outra; soares, r (Autor) FMUP; Prudencio, C (Autor) Outra; Vieira, M (Autor) Outra

Revista

Título: Future Medicinal Chemistry

Vol. 11

Páginas: 645-658

ISSN: 1756-8919

Editora: Future Medicine Ltd.

Indexação

ISI Web of Knowledge - 14 Citações

Scopus - 14 Citações

Outras Informações

ID Authenticus: P-00Q-M87

DOI: 10.4155/fmc-2018-0251

Abstract (EN): Aim: Quinoxaline-1,4-dioxide derivatives are synthetic heterocyclic compounds with multiple biological and pharmacological effects. In this study, we investigated the bioactivity of five quinoxaline-1,4-di-N-oxides derivatives in different animal cell lines. Materials & methods: Using in vitro cell cultures, we evaluated the influence of quinoxaline-1,4-dioxide, 2-methylquinoxaline-1,4-dioxide, 2-amino-3-cyanoquinoxaline-1,4-dioxide, 3-methyl-2-quinoxalinecarboxamide-1,4-dioxide and 2-hydroxyphenazine-N,N-dioxide (2HF) in the viability, migration and proliferation of nonmalignant (3T3-L1 and human dermal microvascular endothelial cell) and malignant (B16-F10, MeWo, GL-261 and BC3H1) cell lines. Results: The viability IC50 concentrations for each quinoxaline-1,4-di-N-oxide derivative were calculated, and a concomitant reduction of migration and proliferation was observed mainly in malignant cell lines. Conclusion: 2HF exhibited potent anti-viability, anti-migration and anti-proliferative actions selectively in tumor cells, nevertheless more studies are required to further investigate 2HF promising biologic effects. [GRAPHICS] .

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14