Anti-Candida activity of antimicrobial impregnated central venous catheters

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

cobrado, l (Autor) FMUP; Silva Dias, A (Autor) Outra; Azevedo, MM (Autor) Outra; rodrigues, ag (Autor) FMUP

Revista

Título: Antimicrobial Resistance and Infection Control

Vol. 6

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00N-6DK

DOI: 10.1186/s13756-017-0269-x

Abstract (EN): Background: Whenever the rate of central line-associated bloodstream infections (CLABSIs) remains high even after the implementation of preventive strategies, the use of chlorhexidine/silver sulfadiazine (CSS) or minocycline/rifampin (MR)-impregnated central venous catheters (CVCs) is currently recommended. Nevertheless, the efficacy of such CVCs against Candida albicans and other emerging non-albicans spp. has been insufficiently studied. This study aims to compare the activity of CSS and MR-impregnated CVCs against the yeasts most frequently isolated from CLABSIs. Methods: For biofilm formation assays, type strains and clinical isolates of C. albicans, C. glabrata and C. parapsilosis sensu stricto were used. Segments of standard polyurethane, MR and second-generation CSS-CVCs were tested. The biofilm metabolic activity was measured by a semi-quantitative XTT reduction assay. Results: CSS catheter segments significantly reduced the biofilm metabolic activity by all tested Candida spp., with inhibition ranging from 60% to 100%. The MR catheter segments promoted C. albicans and C. parapsilosis biofilm formation and exhibited an inconspicuous effect against C. glabrata. Conclusions: Among the recommended antimicrobial CVCs, CSS-CVCs proved to be superior in the inhibition of biofilm formation by the most frequent yeasts causing CLABSIs. Data from this in vitro study may suggest that patients at high risk for invasive candidosis could benefit from the use of CSS-CVCs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7